Materials Based on Bioglass 45S5, Doped with Heavy Elements, for Use as Radiosensitizers

Glass and glass ceramics containing 40 wt.% of heavy metal oxides (Bi, Ta, and W) were obtained for use in medicine as radiosensitizers. The properties of the composites were studied in vitro, including the generation of secondary radiation, chemical solubility, and the variations in the pH of the medium during resorption. The results demonstrated that the secondary radiation indicators and pH value of the medium decreased in the order: W > Ta > Bi. Solubility indices decreased in the order: W > Bi > Ta. Despite the highest generation of secondary ionizing radiation, W-containing ceramics based on Bioglass 45S5 are unsuitable for in vivo use due to their rapid dissolution and high alkalization of the environment.