We study a single-field inflationary scenario with a nontrivial coupling to the Gauss–Bonnet term and compute its predictions for the background dynamics and cosmological perturbations. The model is analyzed within the slow-roll regime, and we derive analytic expressions for the inflationary observables, including the scalar spectral index \(n_s\) , the tensor-to-scalar ratio r, and the running \(\alpha _s\) . Motivated by string-theoretic considerations, we impose the theoretical constraint \(V(\phi )\xi (\phi ) = \text {constant}\) , which reduces the parameter space and provides a more predictive framework. The Gauss–Bonnet coupling modifies the standard consistency relations and enables compatibility with current Planck constraints for a broad parameter range ( \(n_s \in [0.955, 0.970]\) , \(r \in [0.003, 0.09]\) ). We perform a comprehensive Markov Chain Monte Carlo (MCMC) analysis using Planck 2018 and BICEP/Keck data, obtaining posterior constraints on model parameters. Additionally, we examine swampland compatibility, reheating predictions, non-Gaussian signatures, and potential implications for primordial black hole formation. Our analysis demonstrates that this framework provides a well-motivated extension of standard single-field inflation while maintaining observational viability and offering distinctive testable predictions for future cosmological surveys.