<p>Buried pipelines crossing active reverse-slip faults often experience significant bending stresses and strains near the fault rupture plane, leading to structural failure due to global or local buckling mechanisms. This paper employs three-dimensional finite element analysis to investigate the complex buried pipeline-soil interaction under reverse-slip fault movements. The influence of different pipe-soil-fault parameters, viz., fault displacement, dip angle, burial depth, pipeline material and cross-sectional properties, and the soil-pipeline relative stiffness were systematically investigated. Initial analyses were conducted on laboratory-scale pipeline models and benchmarked against available experimental data. Subsequently, parametric analyses were performed to examine the influence of each parameter on pipeline bending strain response and the associated pipeline segment length near the fault plane with high strain concentration, defined as the active length. Field-scale pipeline responses were also simulated for realistic ranges of pipeline-soil parameters. Results are presented in non-dimensional charts for ease of interpretation. A set of non-dimensional combined parameters is introduced, considering the coupling effect of various influencing factors and semi-empirical relationships proposed to predict the peak bending strain and active length in buried pipelines. The predictive methodology provides a valuable tool for assessing the pipeline’s vulnerability to reverse-slip faulting.</p>