<p>The artificially excavated granite residual soil slopes in southern China are frequently prone to instability due to rainfall. The presence of fissures alters the seepage of rainwater, and accelerates the destabilization process of artificial slopes. Therefore, investigating the impact of fissures on seepage fields and slope stability constitutes a crucial scientific foundation for understanding the mechanisms of instability in residual soil slopes. In this paper, the influences of fissure depth, angle and position on stress distribution, seepage field and stability of artificial slope are investigated through numerical simulation. The scenario characterized by the most adverse fissure characteristics is adopted in the flume model test to explore the failure dynamic process of the fissured artificial cutting slope. The following results are obtained: (1) The presence of fissures results in stress concentration on the artificial cutting slope, leading to the horizontal expansion of fissures and exacerbating soil deformation within the zone extending from the fissures to the free surface. (2) Pore water pressure (PWP) and the saturated area exhibit a positive correlation with the fissure depth. The fissure position only affects the seepage field distribution within the depth range of the fissure, and has no effect on the total saturated area of the slope. The increasing fissure angle intensifies the influence of rainwater on the shallow pore water pressure within the slope, and reduces the depth of vertical infiltration. (3) The position of the fissure exerts the most significant effect on the stability of the artificial cutting slope, followed by fissure depth and angle. (4) The instability process of fissured artificial excavation slopes composed of granite residual soil involves slope toe instability, occurrence of preferential flow and fissure-controlled failure, surface and gully erosion, development of tensile fissures, as well as progressive expansion of the sliding zone.</p>