<p>As coal mining depth and intensity increase, the fracture of the thick and hard rock strata during the mining process tends to induce mine earthquakes. In this paper, theoretical analysis, numerical simulation and field monitoring methods are used to study the energy reduction and earthquake mitigation of the deep-hole blasting in deep coal mines. Based on the key stratum theory, the initial fracture span of thick and hard rock strata is calculated. The theoretical calculations are in good agreement with the field monitoring data. At the same time, the numerical model of deep-hole blasting in deep coal mining is established to investigate the mechanisms of energy reduction and earthquake mitigation through blasting. The implementation of deep-hole blasting technology enhances the presplitting and controlled caving of overlying rock strata. After deep-hole blasting, the overburden stress is reduced by 55.7%, and the vertical displacement increases by 62.5%. Based on field monitoring, the effectiveness of deep-hole blasting in controlling mine earthquakes is clarified. After double-side roadway deep-hole blasting, the earthquake events across all energy levels are effectively reduced, and strong mine earthquake events exceeding 10⁵&#xa0;J are not induced. The maximum support resistance and the area of the advanced abutment stress zone are decreased by 13.2% and 41.2%, respectively. The deep-hole blasting technology has achieved a good effect in energy reduction and earthquake mitigation. This study can provide a reference for the research on mine earthquake control technology in deep coal mining.</p>