<p>In this article, which testifies the European dimension of Federigo Enriques, an essential question is raised: is it conceivable to admit a radical antithesis between logical empiricism or neo-empiricism and the Enriquesian view of scientific thought? This paper therefore analyses the relationship between Enriques’ conception of science and that of Otto Neurath, one of the main representatives of neo-empiricism. While the interest towards empiricism in Enriques’ conception of the scientific knowledge is emphasised, it cannot be denied that the relationship of Enriques’ epistemology to the scientific idea of the world appears problematic. However, elements of convergence between Neurath and Enriques are discernible above all in the neo-empiricist principle of verification, in the idea of the unity of science and in the recognition by both of the historical nature of the scientific enterprise. In particular, the comparison is emphasised between Neurath’s idea of the encyclopaedia and Enriques’ rationalism, that highlights how, on closer inspection, Neurath’s critical view is not a true antithesis of the historical perspective of science.</p>