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<p>This study aims to investigate the ameliorative effects of fermented Chinese herbal medicine (FCHM) on manganese (Mn)–induced growth inhibition and liver damage in largemouth bass. The experiment was set up with eight groups: Mn (0, 0.750, 1.125, and 1.688&#xa0;mg/L) and Mn + FCHM (0, 0.750, 1.125, and 1.688&#xa0;mg/L). Among these, the Mn (0&#xa0;mg/L) group served as the control group. The Mn groups were fed a basal diet, while the Mn + FCHM groups were fed a diet containing 1% FCHM. The experiment lasted for 60&#xa0;days. The results indicated that Mn exposure reduced growth performance and induced Mn accumulation in the liver, tissue structural damage, oxidative stress, and inflammation. One percent FCHM partially restored growth performance, increased the activity and gene expression of GSH-PX, CAT, and SOD enzymes in the liver, reduced MDA and Mn content, increased the expression of anti-inflammatory markers <i>IL-10</i> and <i>TGF-β1</i> mRNA, decreased the expression of <i>IL-15</i>, <i>IL-8</i>, <i>IL-1β</i>, and <i>TNF-α</i> mRNA, and alleviated liver tissue pathological damage. In summary, this study found that FCHM can improve the antioxidant capacity of largemouth bass, alleviate Mn-induced liver inflammatory damage, and thereby enhance the growth performance of largemouth bass.</p>

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The ameliorative effects of fermented Chinese herbal medicine on growth inhibition and liver damage induced by manganese exposure in largemouth bass (Micropterus salmoides)

  • 期刊论文

  • 发表日期：

    2025年12月15日

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  • Pan Zhou,
  • Qiuhong Wu,
  • Guang Fan,
  • Zhiwen Yang,
  • Songsong Bao,
  • Jin Li,
  • Xiaofei Yang,
  • Xinyue Liu,
  • Fangzhou Jing,
  • Li Jiang

摘要

This study aims to investigate the ameliorative effects of fermented Chinese herbal medicine (FCHM) on manganese (Mn)–induced growth inhibition and liver damage in largemouth bass. The experiment was set up with eight groups: Mn (0, 0.750, 1.125, and 1.688 mg/L) and Mn + FCHM (0, 0.750, 1.125, and 1.688 mg/L). Among these, the Mn (0 mg/L) group served as the control group. The Mn groups were fed a basal diet, while the Mn + FCHM groups were fed a diet containing 1% FCHM. The experiment lasted for 60 days. The results indicated that Mn exposure reduced growth performance and induced Mn accumulation in the liver, tissue structural damage, oxidative stress, and inflammation. One percent FCHM partially restored growth performance, increased the activity and gene expression of GSH-PX, CAT, and SOD enzymes in the liver, reduced MDA and Mn content, increased the expression of anti-inflammatory markers IL-10 and TGF-β1 mRNA, decreased the expression of IL-15, IL-8, IL-1β, and TNF-α mRNA, and alleviated liver tissue pathological damage. In summary, this study found that FCHM can improve the antioxidant capacity of largemouth bass, alleviate Mn-induced liver inflammatory damage, and thereby enhance the growth performance of largemouth bass.