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<p>This study aimed to develop and validate a Multidimensional Impact of Cancer Risk Assessment questionnaire–Japanese version (MICRA-J) as an assessment of the psychosocial impact of genetic testing. The MICRA was translated into Japanese using standardized translation procedures. The reliability and validity of the MICRA-J were evaluated in individuals who underwent <i>BRCA1</i>/<i>2</i> testing for hereditary breast and ovarian cancer diagnosis. The 72 respondents included patients with <i>BRCA1</i>/<i>2</i> pathogenic variants (n = 20), <i>BRCA1</i>/<i>2</i> negative (n = 35), variants of uncertain significance (VUS, n = 6), participants with cascade testing positive (n = 7), and participants with cascade testing negative (n = 4). Total MICRA-J scores were positively correlated with Hospital Anxiety and Depression Scale (HADS) scores and negatively correlated with the 36-item short-form version 2 acute (SF-36v2 acute) scores (<i>P</i> &lt; 0.05). The MICRA-J showed good internal consistency coefficients (α &gt; 0.70). Furthermore, high test–retest correlations were obtained when the 64 participants responded to the MICRA-J twice within a short period (Pearson’s correlation coefficient = 0.85). The MICRA-J Total score was higher in the groups with <i>BRCA1</i>/<i>2</i> pathogenic variant carriers than in the <i>BRCA1</i>/<i>2</i> negative group, whereas the HADS and SF36v2 acute did not differ significantly. These results suggest that the reliability and validity of the MICRA-J have been established. The MICRA-J, similar to the MICRA in other languages, is considered a useful tool to specifically measure the psychosocial impact of genetic testing.</p>

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Reliability and validity of the multidimensional impact of cancer risk assessment (MICRA) questionnaire: Japanese version

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月3日

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  • Tomoko Watanabe,
  • Kaori Kimura,
  • Minako Kakimoto,
  • Yumie Hiraoka,
  • Manami Matsukawa,
  • Hiroko Nagahashi,
  • Saki Horiguchi,
  • Miwa Toshima,
  • Chikako Tomozawa,
  • Miki Aitani,
  • Takeshi Kuwata,
  • Teruhiko Yoshida,
  • Makoto Hirata,
  • Noriko Tanabe

摘要

This study aimed to develop and validate a Multidimensional Impact of Cancer Risk Assessment questionnaire–Japanese version (MICRA-J) as an assessment of the psychosocial impact of genetic testing. The MICRA was translated into Japanese using standardized translation procedures. The reliability and validity of the MICRA-J were evaluated in individuals who underwent BRCA1/2 testing for hereditary breast and ovarian cancer diagnosis. The 72 respondents included patients with BRCA1/2 pathogenic variants (n = 20), BRCA1/2 negative (n = 35), variants of uncertain significance (VUS, n = 6), participants with cascade testing positive (n = 7), and participants with cascade testing negative (n = 4). Total MICRA-J scores were positively correlated with Hospital Anxiety and Depression Scale (HADS) scores and negatively correlated with the 36-item short-form version 2 acute (SF-36v2 acute) scores (P < 0.05). The MICRA-J showed good internal consistency coefficients (α > 0.70). Furthermore, high test–retest correlations were obtained when the 64 participants responded to the MICRA-J twice within a short period (Pearson’s correlation coefficient = 0.85). The MICRA-J Total score was higher in the groups with BRCA1/2 pathogenic variant carriers than in the BRCA1/2 negative group, whereas the HADS and SF36v2 acute did not differ significantly. These results suggest that the reliability and validity of the MICRA-J have been established. The MICRA-J, similar to the MICRA in other languages, is considered a useful tool to specifically measure the psychosocial impact of genetic testing.