The response of pancreatic acinar cell carcinoma to platinum and olaparib therapy in a germline BRCA2 variant carrier: case report and literature review

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发表日期：

2024年5月11日

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Hiroyuki Matsubayashi,
Akiko Todaka,
Takahiro Tsushima,
Yoshimi Kiyozumi,
Rina Harada,
Eiko Ishihara,
Satomi Higashigawa,
Nobuyuki Ohike,
Hiroki Sakamoto,
Junya Sato,
Hirotoshi Ishiwatari,
Teichi Sugiura,
Katsuhiko Uesaka

摘要

A 73-year-old Japanese man with a history of distal biliary cancer treated by pancreatoduodenectomy developed pancreatic acinar cell carcinoma (PACC) treated by remnant pancreatectomy and adjuvant chemotherapy. Thirteen months after surgery, multiple liver metastases developed and FOLFOX chemotherapy was initiated. Based on the PACC diagnosis and a positive family history for breast and ovarian cancer genetic testing was performed which revealed a pathogenic germline BRCA2 variant (c.8629G > T, p.Glu2877Ter). Olaparib therapy was initiated and the metastases responded well (partial response). PACC is a BRCA2-associated cancer which may respond well to PARP inhibitors.