<p>The paper aims to investigate the interdependent mental and occupational difficulties of all the leading vulnerable groups in the labour force. The study focused on work-related disadvantages and psychosocial burdens of women, young and older workers, demographic and sexual minorities, and the disabled. The workforce is highly heterogeneous, and the uniqueness and diversity should benefit the economy and society. Yet, too often, being a representative of certain groups is a cause for disadvantages and distress in private life and the workplace. The research seems lacking in the aspect of assessing the bias and resulting mental and occupational difficulties of the most vulnerable subpopulations of employees. The subsequent costs burdening the victims of the injustice and the employers, the economy, and society are also understudied and underestimated. However, this related socioeconomic burden exists, and it is excess, unnecessary and, in fact, preventable with the application of targeted multidimensional policies. For the actions taken at the governmental and company levels to be effective, it is necessary to understand the elusive and two-way relationship between work and mental health and the subsequent direct and indirect socioeconomic consequences, particularly for vulnerable employee groups.</p>