<p>Increasingly, spatial conflicts arise from the limited and diverse spatial resources of land–sea interaction (LSI) zones, leading to disordered development. Here, we propose an accurate method of identifying potential territorial spatial conflicts (TSCs) in LSI zones, which is crucial for developing scientific territorial spatial planning and shoreline management plans. With Yancheng City in China as a case study, we defined the LSI zone, constructed index evaluation systems for resources and the environment, and identified potential TSCs by arranging and combining the adjusted multidimensional suitability results. We also identified the conflict status based on a land–sea utilization status conflict Matrix and compared the conflict statuses to validate the proposed method. Subsequently, we analyzed the spatial distribution and relationship between potential TSCs and conflict statuses using spatial overlap and hotspot analyses. The study identified that 23.18% of the LSI zones had high conflicts, 36.18% had medium conflicts, 10.92% had weak conflicts, 2.18% were suitable for agricultural production, 11.61% were suitable for ecological protection, 0.41% were suitable for port–industry–city construction and 15.52% were suitable for fishery breeding. Most non- and weak-conflict zones were concentrated around the eastern coastline in a belt shape, whereas medium- and high-conflict zones were concentrated in the eastern and southern inland areas and dispersed throughout the nearshore seas. The conflict status was divided into four types (coordination, compatibility, conditional compatibility, and antagonism), which showed a pattern of “scattered in the north and clustered in the south.” The spatial distribution of conflict statuses was similar to that of potential TSCs, indicating the rationality and applicability of the proposed method. This study provides a methodological reference for LSI zone management strategies.</p>