<p>Groundwater contamination from industrial and agricultural sources poses a significant threat to water quality, necessitating comprehensive assessment for safe consumption and irrigation. This study evaluates groundwater quality in the Darau and Khamaria canal command area of Udham Singh Nagar district, Uttarakhand, employing multiple approaches, including water quality indices (WQI), hydrogeochemical analysis (Piper &amp; Durov plots), and multivariate statistical analyses including cluster and factor analysis. A total of 23 groundwater samples were analyzed for key physico-chemical parameters, including pH, turbidity, dissolved oxygen, total dissolved solids, major ions, and heavy metals. WQI indicated that groundwater was unsuitable for human consumption at all locations due to excessive concentrations of heavy metals (Fe, Mn, and Cr) exceeding BIS permissible limits. Irrigation water quality indices revealed low-to-moderate water use restrictions at most locations, with recommendations provided to guide farmers on optimal water usage. Hydrogeochemical analysis identified Ca²⁺-Mg²⁺-HCO₃⁻ as the dominant facies with anions in order of CO₃²⁻ &gt; HCO₃⁻ &gt; Cl⁻ &gt; SO₄²⁻ and cations as Mg²⁺ &gt; Ca²⁺ &gt; Na⁺ &gt; K⁺. Cluster analysis grouped the sites into two distinct categories, effectively distinguishing between highly polluted and moderately polluted zones, influenced by varying degrees of industrial and agricultural activities. Furthermore, factor analysis highlighted Cr, Mn, Fe, Zn, and NO₃ as key pollutants. The presence of heavy metals, along with hydrogeochemical patterns, indicates significant contamination primarily from industrial discharge, agricultural runoff, and other anthropogenic activities. These findings underscore the urgent need for effective groundwater management strategies to mitigate contamination risks. Additionally, adopting sustainable irrigation and resource management practices is vital to ensure long-term water quality and sustainability.</p>