<p>This study explores the transformative role of digitalization in enhancing social sustainability within supply chains. Social sustainability, a critical dimension alongside economic and environmental sustainability, aims to balance environmental health and financial stability by improving the quality of life within supply chain networks. Digital technologies introduced by Industry 4.0 and further developed by Industry 5.0 have significantly impacted various aspects of social sustainability. We investigate the interactions and significance of social sustainability enablers influenced by these technologies. Key enablers include worker well-being support, skills development, and equitable educational opportunities. To perform this analysis, we employ the ISM-Fuzzy MICMAC (Matrice d’Impacts Croisés Multiplication Appliquée à un Classement) and DEMATEL (Decision Making Trial and Evaluation Laboratory) methods, which are widely recognized in the literature for their effectiveness. Our findings provide a strategic roadmap for supply chain stakeholders by highlighting the complex relationships between digitalization and social sustainability enablers. We identify key enablers such as digital inclusion, privacy, digital skills, visibility, innovative business design, decision-making, education, and capacity building to achieve a more human-centered and sustainable supply chain. The results clearly reveal the relationships among these enablers, forming a hierarchical structure that underscores their interactions. Additionally, this study contributes to the existing literature by addressing the often-overlooked social dimension of sustainability, offering practical insights for policymakers and business leaders on leveraging digital technologies for sustainable development.</p>