<p>This article assesses the effects of climate change on tourism for a sample of 45 Sub-Saharan African countries, using a Two-Way Fixed Effects (TWFE) estimator, based on country-time fixed effects panel data model over the period 2000–2020. Two key findings emerge: (i) climate change significantly reduces tourism activities in SSA; (ii) The effects of climate change on tourism activities transit through water availability, information and communication technologies (ICT), conflicts, and deforestation. We recommend (i) the implementation of mitigation and adaptation strategies of the tourism sector in the face of climate change, such as the storage and efficient management of available water; (ii) the choice of tourist destinations with less polluting transport means; (iii) the production of agricultural products less vulnerable to extreme climatic conditions; and (iv) the control of corruption, the preservation of peace and security within tourists’ destinations.</p>