<p>This paper investigates the role of lifestyle in determining life expectancy across European countries using spatial regression analysis. In addition to lifestyle variables, our model includes three other groups of determinants: socioeconomic, environmental, and health system characteristics. Alcohol consumption and insufficient intake of fruits and vegetables are significant in all model specifications. Notably, their importance is comparable to income and health expenditure which remain the main drivers of life expectancy. Other lifestyle variables, including smoking, physical activity, and being overweight, exhibit statistically significant effects in alternative model specifications. On the other hand, tertiary education, CO2 emissions, and freshwater resources are not statistically significant. These findings emphasize the need for policymakers to promote healthier lifestyles to enhance population longevity while encouraging individuals to adopt healthier habits to improve their life expectancy. Additionally, the results suggest that European efforts in environmental protection are yielding positive outcomes, as environmental factors do not negatively affect life expectancy.</p>