Scholarlink

<p>The inhalation of pollutants from fossil fuel combustion increases oxidative stress and may cause genotoxic damage, a risk heightened during physical exercise due to increased respiratory rates. This concern extends to equines engaged in intense activities like show jumping. Antioxidant supplementation with vitamin E and selenium may mitigate oxidative stress induced by exercise in polluted environments. This study evaluated the effects of oral supplementation on show jumping horses subjected to physical exertion in urban (<i>n</i> = 10) and peri-urban (<i>n</i> = 10) areas with varying pollution levels. Oxidative stress markers (protein quantification, superoxide dismutase, catalase, and thiobarbituric acid reactive substances), marker of genomic instability (binucleation), and clinical parameters were assessed in relation to environmental nitrogen dioxide (NO<sub>2</sub>) and ozone (O<sub>3</sub>) levels. Results showed that supplementation influenced thiobarbituric acid reactive substances (TBARS), with lower malondialdehyde (MDA) concentration in supplemented groups, especially in urban horses (<i>p</i> = 0.027). DNA damage was reduced in supplemented horses from urban areas with high ozone (O<sub>3</sub>) levels (<i>p</i> = 0.002), but no protective effect was observed in peri-urban horses. These findings suggest that vitamin E and selenium supplementation have antioxidant and DNA-protective impact in urban environments, though their efficacy appears variable in peri-urban areas. Further research incorporating additional pollution markers is necessary to clarify these effects.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effects of vitamin E and selenium supplementation on oxidative stress parameters and marker of genomic instability in show jumping equines exposed to different sources of atmospheric pollution

  • 期刊论文

  • 发表日期：

    2025年8月29日

查看全文
  • Victória dos Santos Gomes,
  • José Vítor dos Santos Marques,
  • Gedaias Noronha da Silva,
  • Bruna Marmett,
  • Eliane Dallegrave

摘要

The inhalation of pollutants from fossil fuel combustion increases oxidative stress and may cause genotoxic damage, a risk heightened during physical exercise due to increased respiratory rates. This concern extends to equines engaged in intense activities like show jumping. Antioxidant supplementation with vitamin E and selenium may mitigate oxidative stress induced by exercise in polluted environments. This study evaluated the effects of oral supplementation on show jumping horses subjected to physical exertion in urban (n = 10) and peri-urban (n = 10) areas with varying pollution levels. Oxidative stress markers (protein quantification, superoxide dismutase, catalase, and thiobarbituric acid reactive substances), marker of genomic instability (binucleation), and clinical parameters were assessed in relation to environmental nitrogen dioxide (NO2) and ozone (O3) levels. Results showed that supplementation influenced thiobarbituric acid reactive substances (TBARS), with lower malondialdehyde (MDA) concentration in supplemented groups, especially in urban horses (p = 0.027). DNA damage was reduced in supplemented horses from urban areas with high ozone (O3) levels (p = 0.002), but no protective effect was observed in peri-urban horses. These findings suggest that vitamin E and selenium supplementation have antioxidant and DNA-protective impact in urban environments, though their efficacy appears variable in peri-urban areas. Further research incorporating additional pollution markers is necessary to clarify these effects.