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<p>Marine mangrove wetlands are ecologically complex ecosystems that serve as rich reservoirs of biologically active compounds with significant biotechnological potential. This review synthesizes current knowledge on mangrove-associated microorganisms and biota, including bacteria, fungi, algae, and invertebrates, with emphasis on their bioassay activities and derived bioactive metabolites. Various analytical approaches, including chromatographic techniques, LC–MS/NMR analysis, and in silico tools, have been employed to identify and characterize compounds such as enzymes, polysaccharides, biosurfactants, and antimicrobial peptides. These biomolecules exhibit diverse functional applications in medicine, environmental management, and industrial processes, including nitrogen fixation, bioremediation, and hydrocarbon degradation. The review highlights that mangrove-derived bioactive compounds are influenced by both ecological interactions and environmental conditions. Furthermore, recent advances indicate a shift toward genome-guided discovery using multi-omics and metagenomic approaches, enabling the identification of novel biosynthetic pathways, particularly from unculturable microorganisms. This integrated approach enhances the efficiency of bioactive compound discovery and supports scalable production through synthetic biology. Overall, mangrove ecosystems represent promising platforms for sustainable biotechnological innovation, underscoring the need for their conservation and the development of integrated validation strategies.</p> Graphical abstract <p></p>

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Discovery of novel bio-resources from the hidden biodiversity of marine mangrove ecosystems

  • 期刊论文

  • 发表日期：

    2026年7月13日

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  • Saranya Mathiyazhagan,
  • Bharathi Balu,
  • Roseline Jebapriya Gunaseelan,
  • Raju Piliyan,
  • Santhanam Perumal,
  • Manoharan Natesan

摘要

Marine mangrove wetlands are ecologically complex ecosystems that serve as rich reservoirs of biologically active compounds with significant biotechnological potential. This review synthesizes current knowledge on mangrove-associated microorganisms and biota, including bacteria, fungi, algae, and invertebrates, with emphasis on their bioassay activities and derived bioactive metabolites. Various analytical approaches, including chromatographic techniques, LC–MS/NMR analysis, and in silico tools, have been employed to identify and characterize compounds such as enzymes, polysaccharides, biosurfactants, and antimicrobial peptides. These biomolecules exhibit diverse functional applications in medicine, environmental management, and industrial processes, including nitrogen fixation, bioremediation, and hydrocarbon degradation. The review highlights that mangrove-derived bioactive compounds are influenced by both ecological interactions and environmental conditions. Furthermore, recent advances indicate a shift toward genome-guided discovery using multi-omics and metagenomic approaches, enabling the identification of novel biosynthetic pathways, particularly from unculturable microorganisms. This integrated approach enhances the efficiency of bioactive compound discovery and supports scalable production through synthetic biology. Overall, mangrove ecosystems represent promising platforms for sustainable biotechnological innovation, underscoring the need for their conservation and the development of integrated validation strategies.

Graphical abstract