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<p>In this work, we investigate anatase-phase TiO<sub>2</sub> nanoparticles as efficient photocatalysts for degrading Reactive Violet 5 (RV5) under natural sunlight exposure. The photocatalytic performance was optimized by studying the effects of pH, catalyst loading, and dye concentration. Under ideal conditions (30&#xa0;mg of TiO<sub>2</sub>, 10&#xa0;mg/L RV5, pH 5.4), up to 96% degradation of RV5 was achieved within 120&#xa0;min. Structural characterization revealed that the nanoparticles possess a porous and granular morphology, contributing to enhanced light absorption and active surface sites. Mechanistic insights point to hydroxyl radicals (·OH) and superoxide species (·O<sub>2</sub>⁻) as the dominant reactive intermediates driving the degradation process. Beyond pollutant remediation, the synthesized TiO<sub>2</sub> nanoparticles exhibited significant anticancer effects. In vitro cytotoxicity assays against MCF-7 cancer cell lines demonstrated a dose-dependent reduction in cell viability, with IC<sub>50</sub> values of 8.96&#xa0;µg/mL, respectively. The therapeutic action is attributed to intracellular ROS generation, leading to oxidative stress-induced apoptosis. These findings underscore the multifunctional potential of anatase TiO<sub>2</sub> nanoparticles as sustainable agents for environmental detoxification. Additionally, TiO<sub>2</sub> nanoparticles demonstrate effective cancer cell suppression, reinforcing their relevance in advanced nanotechnology applications.</p>

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Light-driven photocatalytic TiO2 nanomaterials for environmental pollutant degradation and cancer treatment: emerging strategies and mechanistic perspectives

  • 期刊论文

  • 发表日期：

    2026年1月15日

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  • Yunxia Ran,
  • Ke Xu,
  • Jing Huang

摘要

In this work, we investigate anatase-phase TiO2 nanoparticles as efficient photocatalysts for degrading Reactive Violet 5 (RV5) under natural sunlight exposure. The photocatalytic performance was optimized by studying the effects of pH, catalyst loading, and dye concentration. Under ideal conditions (30 mg of TiO2, 10 mg/L RV5, pH 5.4), up to 96% degradation of RV5 was achieved within 120 min. Structural characterization revealed that the nanoparticles possess a porous and granular morphology, contributing to enhanced light absorption and active surface sites. Mechanistic insights point to hydroxyl radicals (·OH) and superoxide species (·O2⁻) as the dominant reactive intermediates driving the degradation process. Beyond pollutant remediation, the synthesized TiO2 nanoparticles exhibited significant anticancer effects. In vitro cytotoxicity assays against MCF-7 cancer cell lines demonstrated a dose-dependent reduction in cell viability, with IC50 values of 8.96 µg/mL, respectively. The therapeutic action is attributed to intracellular ROS generation, leading to oxidative stress-induced apoptosis. These findings underscore the multifunctional potential of anatase TiO2 nanoparticles as sustainable agents for environmental detoxification. Additionally, TiO2 nanoparticles demonstrate effective cancer cell suppression, reinforcing their relevance in advanced nanotechnology applications.