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<p>This work presents the synthesis of Fe<sub>2</sub>O<sub>3</sub>/CoO<sub><i>x</i></sub> hybrid nanocomposites through a straightforward co-precipitation method, designed to function both as a photocatalyst for environmental remediation and as an anticancer agent. Comprehensive characterization confirmed the structural, morphological, and surface features of the materials. Under visible-light-assisted photo-Fenton conditions, the nanocomposites efficiently degraded tetracycline (TC), achieving a maximum removal of 92.13% in the presence of H<sub>2</sub>O<sub>2</sub>. The degradation kinetics followed a pseudo-first-order model with a high correlation coefficient (R<sup>2</sup> = 0.9865). The catalyst maintained nearly 90% of its activity after four consecutive cycles, demonstrating notable stability and potential for repeated use. Investigation of TC degradation revealed key reactive sites and intermediate products, which helped elucidate the proposed reaction pathways. Beyond their environmental application, the Fe<sub>2</sub>O<sub>3</sub>/CoO<sub><i>x</i></sub> nanocomposites showed marked, concentration-dependent anticancer activity against HCT-15 and MDA-MB-231 cell lines, with IC<sub>50</sub> values of 6.57&#xa0;μg/mL and 7.25&#xa0;μg/mL, respectively. These findings highlight the hybrid material as a versatile platform capable of effective antibiotic degradation and potent anticancer effects, suggesting its promise for integrated environmental and biomedical applications.</p>

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Functional Fe2O3/CoOx hybrid nanocomposites for antibiotic degradation and evaluation of anticancer effects

  • 期刊论文

  • 发表日期：

    2025年10月26日

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  • Mohammad S. Alanazi,
  • Ibrahim O. Alanazi,
  • Mohamed S. Elrobh,
  • Zahid Khan,
  • Abdullah Alamri,
  • Jilani Purusottapatnam

摘要

This work presents the synthesis of Fe2O3/CoOx hybrid nanocomposites through a straightforward co-precipitation method, designed to function both as a photocatalyst for environmental remediation and as an anticancer agent. Comprehensive characterization confirmed the structural, morphological, and surface features of the materials. Under visible-light-assisted photo-Fenton conditions, the nanocomposites efficiently degraded tetracycline (TC), achieving a maximum removal of 92.13% in the presence of H2O2. The degradation kinetics followed a pseudo-first-order model with a high correlation coefficient (R2 = 0.9865). The catalyst maintained nearly 90% of its activity after four consecutive cycles, demonstrating notable stability and potential for repeated use. Investigation of TC degradation revealed key reactive sites and intermediate products, which helped elucidate the proposed reaction pathways. Beyond their environmental application, the Fe2O3/CoOx nanocomposites showed marked, concentration-dependent anticancer activity against HCT-15 and MDA-MB-231 cell lines, with IC50 values of 6.57 μg/mL and 7.25 μg/mL, respectively. These findings highlight the hybrid material as a versatile platform capable of effective antibiotic degradation and potent anticancer effects, suggesting its promise for integrated environmental and biomedical applications.