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<p>Selenium nanoparticles (Se-NPs) have various biomedical, agricultural, and industrial applications. They have been shown to cause a variety of toxicity to aquatic organisms. However, the reproductive toxicity of Se-NPs, especially its potential risk via the transmission from parental fish to offspring remains elusive. In this study, adult Japanese medaka (<i>Oryzias latipes</i>) were fed a Se-NPs spiked diet (20.0 and 200.0&#xa0;µg/g dry weight (dw)) for 21 days in a 2 × 2 factorial mating regime. This full-factorial cross tested all combinations of female and male exposure status (exposed vs. unexposed). The offspring from each treatment were monitored over 28 d (21 d exposure + 7 d depuration) for the determination of the uptake and efflux of Se. The results showed that the Se-NPs exposed male at 20.0&#xa0;µg/g crossed with unexposed female group had a significantly reduced fertilization rate and number of total embryos, while these effects were witnessed in Se-NP treated female only at 200.0&#xa0;µg/g during the period of exposure. The toxicity was maintained during depuration period, indicating delayed and gender-specific effects of Se-NPs. In addition, parental exposure to 200.0&#xa0;µg/g caused elevated embryonic mortality and hatchability as well as severe malformations (including pericardial edema, smaller eyes/heads, curved tails) in the offspring. This study suggests that parental Se-NPs exposure impairs reproduction and offspring development in a gender and concentration-dependent manner, with males being more sensitive to Se-NPs. This study has provided indispensable data for the risk of Se-NPs in fish.</p>

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Dietary selenium nanoparticle shows gender-specific effects on the reproduction of Japanese medaka

  • 期刊论文

  • 发表日期：

    2026年3月24日

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  • Xinyue Xie,
  • Xin Zhang,
  • Lixia Li,
  • Fangli Wu,
  • Hongxing Chen

摘要

Selenium nanoparticles (Se-NPs) have various biomedical, agricultural, and industrial applications. They have been shown to cause a variety of toxicity to aquatic organisms. However, the reproductive toxicity of Se-NPs, especially its potential risk via the transmission from parental fish to offspring remains elusive. In this study, adult Japanese medaka (Oryzias latipes) were fed a Se-NPs spiked diet (20.0 and 200.0 µg/g dry weight (dw)) for 21 days in a 2 × 2 factorial mating regime. This full-factorial cross tested all combinations of female and male exposure status (exposed vs. unexposed). The offspring from each treatment were monitored over 28 d (21 d exposure + 7 d depuration) for the determination of the uptake and efflux of Se. The results showed that the Se-NPs exposed male at 20.0 µg/g crossed with unexposed female group had a significantly reduced fertilization rate and number of total embryos, while these effects were witnessed in Se-NP treated female only at 200.0 µg/g during the period of exposure. The toxicity was maintained during depuration period, indicating delayed and gender-specific effects of Se-NPs. In addition, parental exposure to 200.0 µg/g caused elevated embryonic mortality and hatchability as well as severe malformations (including pericardial edema, smaller eyes/heads, curved tails) in the offspring. This study suggests that parental Se-NPs exposure impairs reproduction and offspring development in a gender and concentration-dependent manner, with males being more sensitive to Se-NPs. This study has provided indispensable data for the risk of Se-NPs in fish.