<p>Overweight and obesity are leading public health concerns, with a global prevalence of 59% and about 74% in the United States. This issue is significant for early childhood leaders, where prior studies have documented close to an 80% prevalence, but also because leader health directly influences their well-being as well as capacity to create supportive environments for children, families, and teachers. For these reasons, understanding what individual and environmental factors are associated with early childhood leader obesity becomes key to any intervention designed to improve these leader health outcomes. Using the Analysis Grid for Environments Linked to Obesity (ANGELO) ecological framework, the goal of this study was to investigate the individual, economic, socio-cultural, and policy-related factors associated with leader overweight and obesity, as measured by Body Mass Index (BMI), from a sample of 1,214 center director and elementary/primary school principals in the United States. Several factors were associated with higher levels of overweight and obesity, including: sedentary behavior, doctor-diagnosed conditions such as diabetes and heart disease, and fast-food intake. Other factors were negatively associated with overweight and obesity including regular exercise, better overall physical health, greater job autonomy and supports, and emotional exhaustion. In addition, female leaders, those working in high poverty schools, or with a bachelor’s degree or lower had higher BMI on average. However, no difference in BMI between ECE center-based and school-based primary/elementary principals was found. These findings carry significant implications for policy and practice aimed at reducing overweight and obesity and promoting health and well-being among early childhood leaders.</p>