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Purpose <p>The aim of this study was to investigate whether Posner-Schlossman Syndrome (PSS), is strictly unilateral, to determine the presence of subclinical abnormalities in the contralateral eye, and to analyze the relationship between retinal function and the corneal sub-basal nerve in such patients.</p> Methods <p>The patients included in this study were diagnosed with PSS. 14 patients with PSS and 21 healthy controls were recruited for this study. Both eyes of the patients and one eye of the healthy controls underwent full-field electroretinography (ffERG) examination. Additionally, in vivo confocal microscopy (IVCM) was performed on the affected eyes of the patients to assess the status of their corneal sub-basal nerve.</p> Results <p>Compared with healthy controls, patients with PSS exhibited significantly reduced amplitudes and abnormal peak times in dark-adapted oscillatory potentials, light-adapted 3 ERG, and light-adapted 30&#xa0;Hz flicker ERG in both eyes. However, no statistically significant differences were observed in dark-adapted 0.01 ERG, dark-adapted 3.0 ERG, and dark-adapted 10.0 ERG. All ffERG parameters in the affected eyes of patients showed no significant correlations with the total nerve length of corneal sub-basal nerve.</p> Conclusions <p>The results demonstrate that PSS is not a strictly unilateral disease. Through ffERG, it is possible to identify cases of bilateral involvement that are difficult to detect, thereby enabling early intervention against potential disease progression.</p>

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Bilateral retinal dysfunction in Posner-Schlossman syndrome: subclinical abnormalities revealed by full-field electroretinography

  • 期刊论文

  • 发表日期：

    2025年11月14日

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  • Xin Ge,
  • Jingyi Li,
  • Xin Xie,
  • Xiaojun He,
  • Zhaoxiang Lu,
  • Yun Feng

摘要

Purpose

The aim of this study was to investigate whether Posner-Schlossman Syndrome (PSS), is strictly unilateral, to determine the presence of subclinical abnormalities in the contralateral eye, and to analyze the relationship between retinal function and the corneal sub-basal nerve in such patients.

Methods

The patients included in this study were diagnosed with PSS. 14 patients with PSS and 21 healthy controls were recruited for this study. Both eyes of the patients and one eye of the healthy controls underwent full-field electroretinography (ffERG) examination. Additionally, in vivo confocal microscopy (IVCM) was performed on the affected eyes of the patients to assess the status of their corneal sub-basal nerve.

Results

Compared with healthy controls, patients with PSS exhibited significantly reduced amplitudes and abnormal peak times in dark-adapted oscillatory potentials, light-adapted 3 ERG, and light-adapted 30 Hz flicker ERG in both eyes. However, no statistically significant differences were observed in dark-adapted 0.01 ERG, dark-adapted 3.0 ERG, and dark-adapted 10.0 ERG. All ffERG parameters in the affected eyes of patients showed no significant correlations with the total nerve length of corneal sub-basal nerve.

Conclusions

The results demonstrate that PSS is not a strictly unilateral disease. Through ffERG, it is possible to identify cases of bilateral involvement that are difficult to detect, thereby enabling early intervention against potential disease progression.