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Background <p>Dolichocolon (DC) is an underrecognized anatomic variant associated with constipation; its association with ulcerative colitis (UC) is unknown.</p> Methods <p>We retrospectively reviewed abdominal MRI and CT scans in children with UC, Crohn’s disease (CD), and non-inflammatory bowel disease (non-IBD) controls, classifying DC subtypes.</p> Results <p>A total of 111 cases (66 with UC) were examined. DC was similarly common (<i>p</i> = 0.4436) in patients with constipated (69%) or non-constipated (NC-UC: 57%) UC. In non-constipated (NC) patients, DC prevalence was higher in children with UC than those with CD or controls. Type 1 DC predominated in NC children with proctitis/left-sided UC (E1/E2), while Type 2 DC was enriched in children with extensive/pancolitis (E3/E4).</p> Discussion <p>DC may be associated with different phenotypes of UC and may influence disease distribution independent of constipation. However, given the cross-sectional design of this study, these associations should be interpreted cautiously and require confirmation in longitudinal studies.</p>

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Dolichocolon May Differentially Associate with Ulcerative Colitis Phenotype in Children

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月25日

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  • Richard Kellermayer,
  • Donovan P. Berens,
  • Réka G. Szigeti

摘要

Background

Dolichocolon (DC) is an underrecognized anatomic variant associated with constipation; its association with ulcerative colitis (UC) is unknown.

Methods

We retrospectively reviewed abdominal MRI and CT scans in children with UC, Crohn’s disease (CD), and non-inflammatory bowel disease (non-IBD) controls, classifying DC subtypes.

Results

A total of 111 cases (66 with UC) were examined. DC was similarly common (p = 0.4436) in patients with constipated (69%) or non-constipated (NC-UC: 57%) UC. In non-constipated (NC) patients, DC prevalence was higher in children with UC than those with CD or controls. Type 1 DC predominated in NC children with proctitis/left-sided UC (E1/E2), while Type 2 DC was enriched in children with extensive/pancolitis (E3/E4).

Discussion

DC may be associated with different phenotypes of UC and may influence disease distribution independent of constipation. However, given the cross-sectional design of this study, these associations should be interpreted cautiously and require confirmation in longitudinal studies.