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<p>Severe acute pancreatitis (SAP) is associated with a broad spectrum of local and systemic complications, among which gastrointestinal bleeding (GIB), although relatively uncommon, confers a disproportionately high mortality risk. The underlying pathogenic mechanisms remain incompletely elucidated and are distinctly multifactorial, involving acute gastric mucosal lesions, stress-induced ulcers, esophageal and gastric varices, and pseudoaneurysm formation and rupture. This review aims to systematically synthesize current evidence on the pathogenesis of SAP-associated GIB, thereby informing the development of targeted intervention strategies, improving the precision of individualized therapeutic decision-making, and ultimately providing a robust theoretical basis to optimize patient outcomes.</p>

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Gastrointestinal Bleeding in Severe Acute Pancreatitis: Pathogenesis and Clinical Management

  • 期刊论文

  • 发表日期：

    2026年2月6日

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  • Chuanyun Wang,
  • Bin Yang

摘要

Severe acute pancreatitis (SAP) is associated with a broad spectrum of local and systemic complications, among which gastrointestinal bleeding (GIB), although relatively uncommon, confers a disproportionately high mortality risk. The underlying pathogenic mechanisms remain incompletely elucidated and are distinctly multifactorial, involving acute gastric mucosal lesions, stress-induced ulcers, esophageal and gastric varices, and pseudoaneurysm formation and rupture. This review aims to systematically synthesize current evidence on the pathogenesis of SAP-associated GIB, thereby informing the development of targeted intervention strategies, improving the precision of individualized therapeutic decision-making, and ultimately providing a robust theoretical basis to optimize patient outcomes.