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Purpose <p>Duodenal eosinophils have been associated with functional dyspepsia, but its association with <i>Helicobacter pylori</i> (<i>H. pylori</i>) remains unclear. Our aim was to investigate the connection between eosinophils in duodenal villi and dyspeptic symptoms, as well as its association with <i>H. pylori</i> infection.</p> Methods <p>We evaluated 100 functional dyspeptic patients, 50 <i>H. pylori</i> positive and 50 <i>H. pylori</i> negative, all meeting Rome III criteria. Participants underwent upper gastrointestinal endoscopy with gastric and duodenal biopsies. Duodenal villi eosinophil were counted in 5 random high-power fields (HPF). We evaluated the association between duodenal villi eosinophils and dyspeptic symptoms using the validated PADYQ questionnaire. Duodenal villi eosinophils were also compared between <i>H. pylori</i>-positive and -negative groups and analyzed according to demographic and endoscopic variables.</p> Results <p>Patients were predominantly female (88%) with a mean age of 41.8&#xa0;years. Median eosinophil/HPF in duodenal villi were 4.6 [2.8–7.2] in <i>H. pylori</i> negative and 4.7 [3.4–8.4] in <i>H. pylori</i> positive subjects (<i>p</i> = 0.40). Duodenal villi eosinophil increased with symptom severity: 3.4 [2.2–6.0] for mild, 4.7 [3.2–6.4] for moderate and 5.8 [3.6–8.2] for severe symptoms (<i>p</i> = 0.03). Multivariate analysis showed that duodenal villi eosinophils were independently associated with smoking (<i>p</i> = 0.02) and symptom severity (<i>p</i> = 0.04).</p> Conclusion <p>Duodenal villi eosinophils did not correlate with <i>H. pylori</i> infection but was associated with dyspepsia symptoms severity.</p>

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Duodenal Villi Eosinophils: Association with Functional Dyspepsia Symptoms, but Not with Helicobacter pylori Infection

  • 期刊论文

  • 发表日期：

    2025年7月24日

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  • Felipe Mazzoleni,
  • Diego de Mendonça Uchoa,
  • Luiz Edmundo Mazzoleni,
  • Carlos Fernando de Magalhães Francesconi,
  • Tobias Cancian Milbradt,
  • Sacha Allebrandt da Silva Ries,
  • Alexandra Cauduro Ponso Fernandes,
  • Pedro Guilherme Schaefer,
  • Liane Golbspan,
  • Helenice Pankowski Breyer,
  • Matheus Truccolo Michalczuk,
  • Eduardo André Ott,
  • Daniel Simon,
  • Nicholas J. Talley

摘要

Purpose

Duodenal eosinophils have been associated with functional dyspepsia, but its association with Helicobacter pylori (H. pylori) remains unclear. Our aim was to investigate the connection between eosinophils in duodenal villi and dyspeptic symptoms, as well as its association with H. pylori infection.

Methods

We evaluated 100 functional dyspeptic patients, 50 H. pylori positive and 50 H. pylori negative, all meeting Rome III criteria. Participants underwent upper gastrointestinal endoscopy with gastric and duodenal biopsies. Duodenal villi eosinophil were counted in 5 random high-power fields (HPF). We evaluated the association between duodenal villi eosinophils and dyspeptic symptoms using the validated PADYQ questionnaire. Duodenal villi eosinophils were also compared between H. pylori-positive and -negative groups and analyzed according to demographic and endoscopic variables.

Results

Patients were predominantly female (88%) with a mean age of 41.8 years. Median eosinophil/HPF in duodenal villi were 4.6 [2.8–7.2] in H. pylori negative and 4.7 [3.4–8.4] in H. pylori positive subjects (p = 0.40). Duodenal villi eosinophil increased with symptom severity: 3.4 [2.2–6.0] for mild, 4.7 [3.2–6.4] for moderate and 5.8 [3.6–8.2] for severe symptoms (p = 0.03). Multivariate analysis showed that duodenal villi eosinophils were independently associated with smoking (p = 0.02) and symptom severity (p = 0.04).

Conclusion

Duodenal villi eosinophils did not correlate with H. pylori infection but was associated with dyspepsia symptoms severity.