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Background <p>Gastroparesis remains an elusive disorder with debilitating symptoms. There has been some progress in treatment options, such as gastric per oral endoscopic pyloromyotomy (G-POEM). It is unknown whether the number of gastric interstitial cells of Cajal (ICC) is related to the outcome of G-POEM.</p> Methods <p>All patients who underwent G-POEM and had gastric muscle biopsy at G-POEM were enrolled. A direct biopsy of the exposed antral smooth muscles was performed during G-POEM to quantify the ICC. The relationship between the outcome of G-POEM and the number of ICC was analyzed.</p> Results <p>Eighty-four patients were included in this study. The average age was 48.5&#xa0;years; 77.6% were females, 47.6% of the patients had diabetic gastroparesis, 16.7% had post-surgical gastroparesis, and 35.7% had idiopathic gastroparesis. All the patients had failed other therapy. 82.9% of the patients had no intra or immediate postoperative complications, and the average procedure time was 29&#xa0;min. 70% of the patients were discharged the same day. The average hospital stay for the rest was 2.6&#xa0;days. The average time to follow-up was 5&#xa0;months. 100% of patients had technical success, and 57.4% of patients had clinical success. The average number of ICC/4&#xa0;mm<sup>2</sup> was 409.14. It was noted that that the number of ICCs is not a predictor of the success of G-POEM.</p> Conclusion <p>The association between the number of ICC and the clinical outcomes of G-POEM is not observed in this study. To our knowledge, this is the first such report. Further research on the pathogenesis of gastroparesis is needed.</p>

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Impact of Interstitial Cells of Cajal Density and Other Factors on Clinical Outcomes Following G-POEM in Gastroparesis Patients

  • 期刊论文

  • 发表日期：

    2025年5月5日

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  • Maryam Mubashir,
  • Daniyal Raza,
  • Michelle Neice,
  • Sofia Novacic,
  • Megan Maloz,
  • Rawia Aburumman,
  • Brittany Pass,
  • Natalie Roppolo,
  • Ross Dies,
  • Kshitij Arora,
  • James Traylor,
  • Hidehiro Takei,
  • Md Ismail Hossain,
  • Mohammad Alfrad Nobel Bhuiyan,
  • Qiang Cai

摘要

Background

Gastroparesis remains an elusive disorder with debilitating symptoms. There has been some progress in treatment options, such as gastric per oral endoscopic pyloromyotomy (G-POEM). It is unknown whether the number of gastric interstitial cells of Cajal (ICC) is related to the outcome of G-POEM.

Methods

All patients who underwent G-POEM and had gastric muscle biopsy at G-POEM were enrolled. A direct biopsy of the exposed antral smooth muscles was performed during G-POEM to quantify the ICC. The relationship between the outcome of G-POEM and the number of ICC was analyzed.

Results

Eighty-four patients were included in this study. The average age was 48.5 years; 77.6% were females, 47.6% of the patients had diabetic gastroparesis, 16.7% had post-surgical gastroparesis, and 35.7% had idiopathic gastroparesis. All the patients had failed other therapy. 82.9% of the patients had no intra or immediate postoperative complications, and the average procedure time was 29 min. 70% of the patients were discharged the same day. The average hospital stay for the rest was 2.6 days. The average time to follow-up was 5 months. 100% of patients had technical success, and 57.4% of patients had clinical success. The average number of ICC/4 mm2 was 409.14. It was noted that that the number of ICCs is not a predictor of the success of G-POEM.

Conclusion

The association between the number of ICC and the clinical outcomes of G-POEM is not observed in this study. To our knowledge, this is the first such report. Further research on the pathogenesis of gastroparesis is needed.