Characteristics and Risk Factors for Postoperative Bleeding Following Endoscopic Resection of Esophageal Squamous Neoplasms

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发表日期：

2024年12月4日

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Daiki Kitagawa,
Takashi Kanesaka,
Ryu Ishihara,
Yasuhiro Tani,
Yuki Okubo,
Yuya Asada,
Tomoya Ueda,
Atsuko Kizawa,
Takehiro Ninomiya,
Yoshiaki Ando,
Gentaro Tanabe,
Yuta Fujimoto,
Hitoshi Mori,
Minoru Kato,
Shunsuke Yoshii,
Satoki Shichijo,
Sachiko Yamamoto,
Koji Higashino,
Noriya Uedo,
Tomoki Michida,
Yasuhiro Fujiwara

摘要

Background

Reports on postoperative bleeding after esophageal endoscopic resection are limited.

Aims

This study aimed to identify the clinical characteristics and risk factors for postoperative bleeding following endoscopic resection of esophageal neoplasms.

Methods

This single-center, retrospective study included consecutive patients who underwent endoscopic resection for esophageal squamous cell carcinoma or squamous intraepithelial neoplasm between January 2018 and December 2022. We investigated the incidence, timing, severity, and risk factors for postoperative bleeding.

Results

Of 1288 patients, 1062 (82%) underwent endoscopic submucosal dissection, and 226 (18%) underwent endoscopic mucosal resection. Postoperative bleeding occurred in seven (0.5%) patients (95% confidence interval [CI] 0.2–1.1%; median postoperative day 8 [range, 4–17 days]). In these seven patients, hemoglobin concentration decreased by a median of 3.0 g/dL (range, 1.6–6.8 g/dL). Antithrombotic agent use, resection wound circumference, and specimen size were significantly associated with postoperative bleeding (P < 0.001, P = 0.002, and P = 0.024, respectively). Among 43 patients who received direct oral anticoagulants (DOACs), postoperative bleeding occurred in four (9%) patients (95% CI 2.6–22.1%). DOACs were significantly associated with postoperative bleeding even after propensity score matching (4/40 [10%] vs. 0/80 [0%], respectively; P = 0.011).

Conclusions

The overall bleeding rate following esophageal endoscopic resection was 0.5%, with a delayed onset, leading to anemia. DOACs emerged as the most significant risk factor for postoperative bleeding.