Abstract <p>A gap exists both in culturally grounded, evidence-informed Native American and Alaska Native (NA/AN) programs and in dissemination and implementation (D&amp;I) approaches to replicate, translate, and adapt such clinical programs. D&amp;I approaches grounded in Indigenous knowledge are needed to translate evidence-informed programs effectively into real-world settings. The purpose of this article is to (a) outline the Weaving Healthy Communities (WHC) D&amp;I approach, with a focus on talking circles, and (b) provide results of talking circle feedback from the culturally adapted and efficacious Chukka Auchaffi’ Natana (in Choctaw language) or Weaving Healthy Families program (WHF). WHF promotes resilience and wellness, while preventing problem alcohol and other drug use, violence, and mental health conditions among NA/ANs. Using a community-based, critical ethnography with a southeastern tribe in the United States, quarterly talking circles were conducted after each cohort of WHF participants (i.e., families and facilitators) completed their intervention. Thematic data analysis revealed important themes of core WHF components, along with participants’ desires for extended programs that could benefit NA communities. The most frequently reported theme was <i>talking circle benefits</i>, coded 228 times. Within this theme, prominent subthemes included: <i>building trust; providing stress relief and offsetting personal burdens; learning from listening; fostering positive communication; sharing within the same peer groups; and help with problem and solution identification</i>. Social work professionals integrating talking circles with NA/AN families should leverage tribal community facilitators and coleadership, tailor to local tradition and culture, center relationality and confidentiality, use developmentally tailored peer groups, and extend support beyond sessions.</p> Clinical Trial: <p>The Weaving Healthy Families Program: NCT03924167.</p>