Background <p>This randomized controlled study examined the effectiveness of face-to-face versus web-based Eye Movement Desensitization and Reprocessing (EMDR) for Generalized Anxiety Disorder (GAD).</p> Method <p>Sixty-five patients were randomly assigned to face-to-face EMDR (<i>n</i> = 23), web-based EMDR (<i>n</i> = 23), or a waiting-list control condition (WLCC) (<i>n</i> = 23). Treatment consisted of ten sessions. Symptom changes were assessed post-treatment and at one- and three-month follow-ups using the Generalized Anxiety Disorder 7-Item scale, Penn State Worry Questionnaire, State-Trait Anxiety Inventory, and Beck Anxiety Inventory. Participants also recorded daily anxiety and worry levels from two weeks before treatment to two weeks after follow-up.</p> Results <p>Linear mixed-model analyses showed significant improvements in both treatment conditions compared to WLCC, with large effect sizes (e.g., GAD-7: d_pre−post = 1.90 for face-to-face, d_pre−post = 1.59 for web-based). No significant differences between treatment conditions were found, except for worry. Treatment effects remained stable at follow-ups.</p> Conclusions <p>Both face-to-face and web-based EMDR are effective for GAD. However, because wait-list control is used, symptom improvements cannot be attributed solely to EMDR. Future studies using active control groups are warranted.</p> Ethics <p>Approved by the Research Ethics Committee of Bushehr University of Medical Science (IR.BPUMS.REC.1402.070) and registered retrospectively in the Iranian Registry of Clinical Trials (IRCT20240716062442N1).</p>