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<p>Two new compounds (<b>1</b> and <b>2</b>) and six known compounds (<b>3–8</b>) were isolated from the endophytic fungus <i>Aspergillus fumigatus</i> J2-22-1, and their structures were elucidated through comprehensive NMR spectroscopy and HR-ESI-MS analyses. All compounds were evaluated for PTP1B inhibitory activity. Notably, compound <b>1</b> demonstrated significant inhibition with an IC<sub>50</sub> value of 7.36 μM, demonstrating comparable potency with the positive control Na<sub>3</sub>VO<sub>4</sub>. These findings underscore the potential of fungal metabolites as promising sources for developing novel PTP1B inhibitors.</p>

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New PTP1B Inhibitory Metabolite from the Endophytic Fungus Aspergillus fumigatus J2-22-1

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Jintao Wang,
  • Meng Ren,
  • Liyue Su,
  • Li Zhang,
  • Tianxiang Zhang,
  • Jun Zhang,
  • Sijun Dong,
  • Dan Ma,
  • Du-Qiang Luo

摘要

Two new compounds (1 and 2) and six known compounds (3–8) were isolated from the endophytic fungus Aspergillus fumigatus J2-22-1, and their structures were elucidated through comprehensive NMR spectroscopy and HR-ESI-MS analyses. All compounds were evaluated for PTP1B inhibitory activity. Notably, compound 1 demonstrated significant inhibition with an IC50 value of 7.36 μM, demonstrating comparable potency with the positive control Na3VO4. These findings underscore the potential of fungal metabolites as promising sources for developing novel PTP1B inhibitors.