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<p>A new unusual sesquiterpene alkaloid (<b>1</b>), as well as four known sesquiterpenes (<b>2–5</b>) were isolated from the fermentation broth of the cigar tobacco-derived <i>Aspergillus ustus</i>. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound <b>1</b> was tested for its antibacterial activity against five pathogenic strains (<i>Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Bacillus subtilis,</i> and <i>Proteus</i> spp.). The results revealed that compound <b>1</b> showed high antibacterial activity with bacteriostatic diameter within the range 19.2 ± 1.4~24.8 ± 1.6 mm, and most of the bacteriostatic diameters of compound <b>1</b> are higher than that of the positive control. This compound has the potential to be used as a natural preservative.</p>

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A New Antibacterial Sesquiterpene Alkaloid from the Cigar-Tobacco-Derived Aspergillus ustus

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Heng Yao,
  • Wen-Bing Zhou,
  • Jing Li,
  • Zhi-Hua Huang,
  • Gao-Kun Zhao,
  • Yong Xu,
  • Yu-Long Su,
  • Guang-Hai Zhang,
  • Guang-Hui Kong,
  • Yu-Ping Wu,
  • Jin Wang

摘要

A new unusual sesquiterpene alkaloid (1), as well as four known sesquiterpenes (2–5) were isolated from the fermentation broth of the cigar tobacco-derived Aspergillus ustus. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 1 was tested for its antibacterial activity against five pathogenic strains (Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Bacillus subtilis, and Proteus spp.). The results revealed that compound 1 showed high antibacterial activity with bacteriostatic diameter within the range 19.2 ± 1.4~24.8 ± 1.6 mm, and most of the bacteriostatic diameters of compound 1 are higher than that of the positive control. This compound has the potential to be used as a natural preservative.