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<p>One new isopimarane diterpene glycoside, xylariside D (<b>1</b>), and five known analogs (<b>2–6</b>) were identified from the secondary metabolites of the plant-derived endophytic fungus <i>Xylaria</i> sp. ZY-13. The chemical structure of compound <b>1</b> was elucidated using 1D and 2D NMR, HR-ESI-MS, ECD spectral analysis, and other spectroscopic methods. These compounds exhibit intriguing structures characterized by diterpenes linked to sugar groups. Additionally, the anti-inflammatory activities of all compounds were evaluated. The results indicate that only compounds <b>5</b> and <b>6</b> exhibit weak anti-inflammatory activities.</p>

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A New Isopimarane Diterpene Glycoside from Endophytic Fungus Xylaria sp. ZY-13

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Wang Shou-dong,
  • Zhang Ming-yue,
  • Song Yong-qi,
  • Chen Xiao-hui,
  • Liu Bao-guang,
  • Feng Yu-xiao,
  • Shi Jia-qi,
  • Feng Shu-ying,
  • Guo Tao

摘要

One new isopimarane diterpene glycoside, xylariside D (1), and five known analogs (2–6) were identified from the secondary metabolites of the plant-derived endophytic fungus Xylaria sp. ZY-13. The chemical structure of compound 1 was elucidated using 1D and 2D NMR, HR-ESI-MS, ECD spectral analysis, and other spectroscopic methods. These compounds exhibit intriguing structures characterized by diterpenes linked to sugar groups. Additionally, the anti-inflammatory activities of all compounds were evaluated. The results indicate that only compounds 5 and 6 exhibit weak anti-inflammatory activities.