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<p>Two new aromatic sesquiterpenes, 2-isopropyl-5-methyl-4-(4-methylfuran-2-yl)phenol (<b>1</b>) and 5-(hydroxymethyl)-2-isopropyl-4-(4-methylfuran-2-yl)phenol (<b>2</b>), as well as five known ones (<b>3–7</b>) were isolated from the stem bark of cigar tobacco. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. The antiviral activity of compounds <b>1</b> and <b>2</b> against tobacco mosaic virus (TMV) were detected. Interestingly, compounds <b>1</b> and <b>2</b> exhibited potential anti-TMV activities with inhibition rates with inactivation effects 30.8% and 36.4%, and a protective effect of 32.5% and 34.9%, respectively. These rates are close to that of the positive control.</p>

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Two New Antiviral Aromatic Sesquiterpenes from the Stem Bark of Cigar Tobacco

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Jin Wang,
  • Zhi-Hua Huang,
  • Heng Yao,
  • Gao-Kun Zhao,
  • Yu-Long Su,
  • Guang-Hai Zhang,
  • Yong Xu,
  • Yu-Ping Wu,
  • Guang-Hui Kong,
  • Jing Li,
  • Wen-Bing Zhou

摘要

Two new aromatic sesquiterpenes, 2-isopropyl-5-methyl-4-(4-methylfuran-2-yl)phenol (1) and 5-(hydroxymethyl)-2-isopropyl-4-(4-methylfuran-2-yl)phenol (2), as well as five known ones (3–7) were isolated from the stem bark of cigar tobacco. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. The antiviral activity of compounds 1 and 2 against tobacco mosaic virus (TMV) were detected. Interestingly, compounds 1 and 2 exhibited potential anti-TMV activities with inhibition rates with inactivation effects 30.8% and 36.4%, and a protective effect of 32.5% and 34.9%, respectively. These rates are close to that of the positive control.