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<p>A new phenylpropanoid 3-(2′-hydroxy-3′,4′,5′-trimethoxyphenyl)-propanoic acid (<b>1</b>), together with 12 known compounds, were isolated from the methanol extract of the leaves of <i>Cryptocarya yunnanensis</i>. Their structures were elucidated on the basis of spectroscopic analysis, including HR-ESI-MS, IR, 1D and 2D NMR spectroscopy. Cytotoxic properties of compounds <b>1</b>, <b>2</b>, <b>3</b>, and <b>5</b> were evaluated against five human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480). Compound <b>5</b> showed moderate cytotoxicity against the tested cell lines with IC<sub>50</sub> of 7.5–37.5 μΜ.</p>

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A New Phenylpropanoid from Cryptocarya yunnanensis

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Ru-qin Xiong,
  • Tian-zhen Xie,
  • Sheng-Jian Li,
  • Zheng-biao Zhang,
  • Zhong-xia Zhao,
  • Ye-gao Chen

摘要

A new phenylpropanoid 3-(2′-hydroxy-3′,4′,5′-trimethoxyphenyl)-propanoic acid (1), together with 12 known compounds, were isolated from the methanol extract of the leaves of Cryptocarya yunnanensis. Their structures were elucidated on the basis of spectroscopic analysis, including HR-ESI-MS, IR, 1D and 2D NMR spectroscopy. Cytotoxic properties of compounds 1, 2, 3, and 5 were evaluated against five human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480). Compound 5 showed moderate cytotoxicity against the tested cell lines with IC50 of 7.5–37.5 μΜ.