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<p>Two new biphenyls, 3,4′ ,5-trimethoxy-3′-(4-methylfuran-2-yl)-[1,1′-biphenyl]-4-ol (<b>1</b>) and 3′-(4-(hydroxymethyl)furan-2-yl)-3,4′,5-trimethoxy-[1,1′-biphenyl]-4-ol (<b>2</b>), along with five known ones (<b>3–7</b>) were isolated from the fermentation products of a sun-cured tobacco-derived endophytic fungus <i>Aspergillus fumigatus</i>. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> were evaluated for their antifungal activity against Golovinomyces cichoracearum (the main pathogenic sources of tobacco powdery mildew disease). Compounds <b>1</b> and <b>2</b> showed potential anti-<i>G</i>. cichoracearum activity with inhibition rates of 76.8% ± 4.8, and 85.6% ± 4.6, respectively, compared with the negative control. These rates are close to that of the positive control (with an inhibition rate of 88.4% ± 5.5).</p>

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Bioactivity Biphenyls from Sun-Cured Tobacco-Derived Endophytic Fungus Aspergillus fumigatus

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Jing Li,
  • Zhi-Hua Huang,
  • Shu-Hao Xu,
  • Yong Xu,
  • Chao Min,
  • Biao Li,
  • Zheng-Nan Jia,
  • Jin Wang,
  • Jue-Ting Liu,
  • Yi-Shan Duan,
  • Wen-Bing Zhou

摘要

Two new biphenyls, 3,4′ ,5-trimethoxy-3′-(4-methylfuran-2-yl)-[1,1′-biphenyl]-4-ol (1) and 3′-(4-(hydroxymethyl)furan-2-yl)-3,4′,5-trimethoxy-[1,1′-biphenyl]-4-ol (2), along with five known ones (3–7) were isolated from the fermentation products of a sun-cured tobacco-derived endophytic fungus Aspergillus fumigatus. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their antifungal activity against Golovinomyces cichoracearum (the main pathogenic sources of tobacco powdery mildew disease). Compounds 1 and 2 showed potential anti-G. cichoracearum activity with inhibition rates of 76.8% ± 4.8, and 85.6% ± 4.6, respectively, compared with the negative control. These rates are close to that of the positive control (with an inhibition rate of 88.4% ± 5.5).