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<p>A new resveratrol derivative, <i>trans</i>-resveratrol-4′-<i>O</i>-gallate (<b>1</b>), has been isolated from the leaves of <i>Polygonum multiflorum</i>, together with eight known compounds, resveratrol (<b>2</b>), 2,3,5,4′-tetrahydroxystilbene-2-<i>O-β</i>-D-glucoside (<b>3</b>), emodin (<b>4</b>), chrysophanol (<b>5</b>), tricin (<b>6</b>), apigenin (<b>7</b>), gallic acid (<b>8</b>), and methyl gallate (<b>9</b>). The structure of the new compound <b>1</b> was determined using spectroscopic and MS analyses. Among the isolates, <i>trans</i>-resveratrol-4′-O-gallate (<b>1</b>), resveratrol (<b>2</b>), emodin (<b>4</b>), and apigenin (<b>7</b>) showed potent inhibition with IC<sub>50</sub> values of 8.27 ± 0.54, 12.74 ± 1.28, 13.02 ± 0.52, and 11.75 ± 1.07 μM, respectively, against LPS-induced nitric oxide generation. In addition, compounds <b>1</b>, <b>2</b>, <b>8</b>, and <b>9</b> also showed potent DPPH radical scavenging activities, with IC<sub>50</sub> values of 7.28 ± 0.57, 13.48 ± 1.25, 15.17 ± 1.36, and 35.06 ± 2.69 μM, respectively.</p>

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Anti-Inflammatory and Antioxidant Constituents from Polygonum multiflorum

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Li-Chai Chen,
  • Chien-Ming Huang,
  • Zih-Rong Chen,
  • Chia-Ching Liaw,
  • Ming-Jen Cheng,
  • Jen-Wen Hsiao,
  • Jih-Jung Chen

摘要

A new resveratrol derivative, trans-resveratrol-4′-O-gallate (1), has been isolated from the leaves of Polygonum multiflorum, together with eight known compounds, resveratrol (2), 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (3), emodin (4), chrysophanol (5), tricin (6), apigenin (7), gallic acid (8), and methyl gallate (9). The structure of the new compound 1 was determined using spectroscopic and MS analyses. Among the isolates, trans-resveratrol-4′-O-gallate (1), resveratrol (2), emodin (4), and apigenin (7) showed potent inhibition with IC50 values of 8.27 ± 0.54, 12.74 ± 1.28, 13.02 ± 0.52, and 11.75 ± 1.07 μM, respectively, against LPS-induced nitric oxide generation. In addition, compounds 1, 2, 8, and 9 also showed potent DPPH radical scavenging activities, with IC50 values of 7.28 ± 0.57, 13.48 ± 1.25, 15.17 ± 1.36, and 35.06 ± 2.69 μM, respectively.