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<p><i>Dicranopteris linearis</i>, a plant species widely used in traditional Vietnamese medicine, was subjected to phytochemical investigation. A new flavonoid glycoside, kaempferol-3-<i>O</i>-(4″,6″-di(<i>E-p</i>-coumaroyl)-<i>β</i>-D-glucopyranoside (<b>1</b>), together with three known compounds, shikimic acid (<b>2</b>), angelicin (<b>3</b>), and 3,4-dihydroxycinnamic acid (<b>4</b>), were isolated and structurally elucidated from the spores of <i>D. linearis</i>. Evaluation of the <i>α</i>-glucosidase inhibitory activity of <b>1–4</b> revealed that <b>1</b> exhibited significant activity, with an IC<sub>50</sub> value of 22.5 μM.</p>

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A New Flavonoid Glycoside from Dicranopteris linearis Spores

  • 期刊论文

  • 发表日期：

    2026年6月19日

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  • Nguyen-Hong-Nhi Phan,
  • Thi-Phuong Nguyen,
  • Ngoc-Hong Nguyen,
  • Huy-Truong Nguyen,
  • Thuc-Huy Duong,
  • Nguyen-Khanh-Duy Kieu,
  • Huynh-Thanh-Duy Bui,
  • Jirapast Sichaem

摘要

Dicranopteris linearis, a plant species widely used in traditional Vietnamese medicine, was subjected to phytochemical investigation. A new flavonoid glycoside, kaempferol-3-O-(4″,6″-di(E-p-coumaroyl)-β-D-glucopyranoside (1), together with three known compounds, shikimic acid (2), angelicin (3), and 3,4-dihydroxycinnamic acid (4), were isolated and structurally elucidated from the spores of D. linearis. Evaluation of the α-glucosidase inhibitory activity of 1–4 revealed that 1 exhibited significant activity, with an IC50 value of 22.5 μM.