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<p>Two new naphthalene derivatives, 1-acetyl-5-isopropyl-2,7-dimethoxynaphthalene (<b>1</b>) and 1-acetyl-5-isopropyl-2,8-dimethoxynaphthalene (<b>2</b>), together with five known analogs (<b>3–7</b>) were isolated from the fermentation products of an endophytic fungus <i>Phomopsis fukushii</i> originating from cigar tobacco. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds <b>1</b> and <b>2</b> were evaluated for their anti-methicillin-resistant <i>Staphylococcus aureus</i> (anti-MRSA) activity. The results showed that compounds <b>1</b> and <b>2</b> showed weak inhibition with IZD of 9.4 ± 1.6 and 10.6 ± 1.8 mm, respectively.</p>

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Antibacterial Napthalene Derivatives from the Fermentation Products of an Endophytic Fungus Phomopsis fukushii

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Gao-Kun Zhao,
  • Wen-Bing Zhou,
  • Heng Yao,
  • Yu-Long Su,
  • Guang-Hai Zhang,
  • Yu-Ping Wu,
  • Wei-Guang Wang,
  • Guang-Hui Kong,
  • Zhi-Hua Huang

摘要

Two new naphthalene derivatives, 1-acetyl-5-isopropyl-2,7-dimethoxynaphthalene (1) and 1-acetyl-5-isopropyl-2,8-dimethoxynaphthalene (2), together with five known analogs (3–7) were isolated from the fermentation products of an endophytic fungus Phomopsis fukushii originating from cigar tobacco. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds 1 and 2 showed weak inhibition with IZD of 9.4 ± 1.6 and 10.6 ± 1.8 mm, respectively.