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<p>A convenient method for synthesizing<i> N</i>-substituted 1-benzyl-2-aminobenzimidazole derivatives that combines condensation with natural aldehydes, azeotropic distillation, and <i>in situ</i> reduction was proposed. The products were tested for <i>in vitro</i> antioxidant activity using FRAP, DPPH, and ABTS tests. Compounds with an OH group in the <i>para</i>- and <i>meta</i>-positions were most active in the FRAP and DPPH tests; with <i>ortho</i>-substitution, in the ABTS test. Compounds <b>3a–c</b> exhibited high inhibitory activity against nitric oxide.</p>

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Synthesis of N-Substituted Derivatives of 1-Benzyl-2-Aminobenzimidazole Using Natural Aldehydes and Their Antioxidant Activity

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • B. I. Sakhautdinov,
  • T. A. Sapozhnikova,
  • T. R. Nugumanov,
  • R. G. Farkhutdinov

摘要

A convenient method for synthesizing N-substituted 1-benzyl-2-aminobenzimidazole derivatives that combines condensation with natural aldehydes, azeotropic distillation, and in situ reduction was proposed. The products were tested for in vitro antioxidant activity using FRAP, DPPH, and ABTS tests. Compounds with an OH group in the para- and meta-positions were most active in the FRAP and DPPH tests; with ortho-substitution, in the ABTS test. Compounds 3a–c exhibited high inhibitory activity against nitric oxide.