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<p>With the aim of screening more antibacterial metabolites, in this study, two new furo[3,2-<i>h</i>]isoquinolines (<b>1</b> and <b>2</b>), together with five known (<b>3–7</b>) analogues, were isolated from the <i>Nicotiana tabacum</i>-derived endophytic fungi <i>Aspergillus fumigatus</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Interestingly, compounds <b>1</b> and <b>2</b> exhibited notable antibacterial activity with a bacteriostatic diameter in the range of 16.2 ± 2.2 – 22.6 ± 2.3 mm against five nitrosobacteria strains; most of the bacteriostaticic diameter were higher than that of the positive control.</p>

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Two New Furo[3,2-h]isoquinolines from the Nicotiana tabacum-Derived Aspergillus fumigatus

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • Hua-Yin Liu,
  • Rong Zhang,
  • Gao-Feng Dong,
  • Jing Liu,
  • Jing Li,
  • Yong Xu,
  • Jin Wang,
  • Guang-Yu Yang,
  • Qiu-Fen Hu,
  • Shi-Ping Zhou

摘要

With the aim of screening more antibacterial metabolites, in this study, two new furo[3,2-h]isoquinolines (1 and 2), together with five known (3–7) analogues, were isolated from the Nicotiana tabacum-derived endophytic fungi Aspergillus fumigatus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Interestingly, compounds 1 and 2 exhibited notable antibacterial activity with a bacteriostatic diameter in the range of 16.2 ± 2.2 – 22.6 ± 2.3 mm against five nitrosobacteria strains; most of the bacteriostaticic diameter were higher than that of the positive control.