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<p>An effective method for adding an N atom to the C4-position of lappaconitine was developed. New derivatives (C4-<i>N</i>-derivative of lappaconitine and three of its sulfanilamide analogs) were prepared. Of these, compound <b>7</b> possessed pronounced antiarrhythmic activity, did not cause lethal outcomes, and did not exhibit proarrhythmic effects at the studied doses in mice.</p>

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Synthesis and Assessment of Antiarrhythmic Properties of C4-Amino Derivatives of Lappaconitine

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • B. Wang,
  • B. Zhao,
  • W. Xue,
  • Sh. Sh. Sagdullaev,
  • J. Zhao

摘要

An effective method for adding an N atom to the C4-position of lappaconitine was developed. New derivatives (C4-N-derivative of lappaconitine and three of its sulfanilamide analogs) were prepared. Of these, compound 7 possessed pronounced antiarrhythmic activity, did not cause lethal outcomes, and did not exhibit proarrhythmic effects at the studied doses in mice.