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<p>A new isocoumarin derivative, namely stoloniferol Z (<b>1</b>), and four known compounds (<b>2</b>–<b>5</b>) were isolated from the desert-derived fungus <i>Aspergillus foeniculicola</i> H1-24. Their structures were determined by detailed analysis of 1D and 2D NMR and MS data. All the isolates were evaluated for cytotoxic activity. Compound <b>3</b> exhibited a certain degree of antitumor activity against C33A with IC<sub>50</sub> values of 29.26 μg/mL, compared to cisplatin (IC<sub>50</sub> = 18.81 μg/mL). The other compounds exhibited weak cytotoxic activity with IC<sub>50</sub> values ranging from 19.47 μg/mL to 81.96 μg/mL.</p>

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A New Isocoumarin Derivative from the Soil-Derived Fungus Aspergillus foeniculicola H1-24

  • 期刊论文

  • 发表日期：

    2026年3月1日

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  • Jin-Jie Liu,
  • Xin-Yi Zhai,
  • Cui-duan Wang,
  • Qing-Wang Liu,
  • Jin-Xiu Zhang,
  • Jian-Hua Lv,
  • Zhuang Li

摘要

A new isocoumarin derivative, namely stoloniferol Z (1), and four known compounds (2–5) were isolated from the desert-derived fungus Aspergillus foeniculicola H1-24. Their structures were determined by detailed analysis of 1D and 2D NMR and MS data. All the isolates were evaluated for cytotoxic activity. Compound 3 exhibited a certain degree of antitumor activity against C33A with IC50 values of 29.26 μg/mL, compared to cisplatin (IC50 = 18.81 μg/mL). The other compounds exhibited weak cytotoxic activity with IC50 values ranging from 19.47 μg/mL to 81.96 μg/mL.