Scholarlink

<p>The mnestic activity of synthetic derivatives of the alkaloid (–)-cytisine with a thiourea substituent in the 3- and 9-position was studied in a conditioned passive avoidance response (CPAR) test. Four candidate compounds with mnestic activity comparable to or exceeding that of the reference drug piracetam were identified among 26 tested derivatives. One of the compounds, the ethyl ester of 2{3-[(1<i>R</i>,5<i>S</i>)-3-methyl-8-oxo-2,3,4,5,6,8-hexahydro-1<i>H</i>-1,5-methanopyrido[1,2-<i>a</i>][1,5]diazocin-9-yl]thioureido}acetic acid, which was prepared by reacting methylcytisine 9-isothiocyanate with ethyl glycinate, exhibited 100% mnestic activity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Thioureas of the (–)-Cytisine Series with Mnestic Activity

  • 期刊论文

  • 发表日期：

    2025年11月20日

查看全文
  • A. V. Koval’skaya,
  • V. A. Sorokina,
  • S. F. Gabdrakhmanova,
  • N. S. Makara,
  • T. A. Sapozhnikova,
  • I. P. Tsypysheva

摘要

The mnestic activity of synthetic derivatives of the alkaloid (–)-cytisine with a thiourea substituent in the 3- and 9-position was studied in a conditioned passive avoidance response (CPAR) test. Four candidate compounds with mnestic activity comparable to or exceeding that of the reference drug piracetam were identified among 26 tested derivatives. One of the compounds, the ethyl ester of 2{3-[(1R,5S)-3-methyl-8-oxo-2,3,4,5,6,8-hexahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-9-yl]thioureido}acetic acid, which was prepared by reacting methylcytisine 9-isothiocyanate with ethyl glycinate, exhibited 100% mnestic activity.