Scholarlink

<p>A new pyrrolidine alkaloid, lobelialsine (<b>1</b>), has been isolated from the aerial part of <i>Lobelia alsinoides</i> subsp. <i>hancei</i>, together with eight known compounds, lobelanidine (<b>2</b>), lobeline (<b>3</b>), luteolin (<b>4</b>), apigenin (<b>5</b>), naringenin (<b>6</b>), hesperetin (<b>7</b>), scoparone (<b>8</b>), and isoscopoletin (<b>9</b>). The structure of the new compound <b>1</b> was determined through spectroscopic and MS analyses. Among the isolated compounds, lobelialsin (<b>1</b>), luteolin (<b>4</b>), apigenin (<b>5</b>), and naringenin (<b>6</b>) showed potent inhibition with IC<sub>50</sub> values of 18.31 ± 1.34, 17.49 ± 1.06, 15.49 ± 0.94, and 25.47 ± 1.83 μM, respectively, against LPS-induced NO generation. In addition, compounds <b>1</b>, <b>4</b>, <b>5</b>, and <b>6</b> also showed potent DPPH radicals scavenging activities with SC<sub>50</sub> values of 27.92 ± 2.17, 12.28 ± 0.69, 38.63 ± 2.75, and 55.01 ± 4.80 μM, respectively.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A New Pyrrolidine Alkaloid and Anti-Inflammatory and Antioxidant Constituents from Lobelia alsinoides subsp. hancei

  • 期刊论文

  • 发表日期：

    2025年11月18日

查看全文
  • Chu-Wen Kuo,
  • Zih-Rong Chen,
  • Hsueh-Yang Huang,
  • Chien-Ming Huang,
  • Ming-Jen Cheng,
  • Fu-Sen Wu,
  • Jih-Jung Chen

摘要

A new pyrrolidine alkaloid, lobelialsine (1), has been isolated from the aerial part of Lobelia alsinoides subsp. hancei, together with eight known compounds, lobelanidine (2), lobeline (3), luteolin (4), apigenin (5), naringenin (6), hesperetin (7), scoparone (8), and isoscopoletin (9). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, lobelialsin (1), luteolin (4), apigenin (5), and naringenin (6) showed potent inhibition with IC50 values of 18.31 ± 1.34, 17.49 ± 1.06, 15.49 ± 0.94, and 25.47 ± 1.83 μM, respectively, against LPS-induced NO generation. In addition, compounds 1, 4, 5, and 6 also showed potent DPPH radicals scavenging activities with SC50 values of 27.92 ± 2.17, 12.28 ± 0.69, 38.63 ± 2.75, and 55.01 ± 4.80 μM, respectively.