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<p>The fruits of Vietnamese <i>Garcinia schomburgkiana</i> were subjected to chemical investigation, leading to the isolation and characterization of a previously unreported benzoylphloroglucinol, 8-benzoyl-2-(4-methylpenten-3-yl)-chromane-5,7-diol (<b>1</b>), along with two known compounds, 8-benzoyl-2-(4-methylpenten-3-yl)-chromane-3,5,7-triol (<b>2</b>) and 5-benzoyl-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1<i>H</i>-xanthene-6,8-diol (<b>3</b>). The structural elucidation was achieved through extensive spectroscopic methods, including NMR and HR-ESI-MS. Compound <b>1</b> exhibited good α-glucosidase inhibition with an IC<sub>50</sub> value of 30.2 ± 5.3 μM.</p>

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A New Benzoylphloroglucinol Isolated from the Fruits of Garcinia schomburgkiana

  • 期刊论文

  • 发表日期：

    2025年11月18日

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  • Nguyen-Hong-Nhi Phan,
  • Thuc-Huy Duong,
  • Thi-Kim-Dung Le,
  • Huy Truong Nguyen,
  • Ngoc-Hong Nguyen,
  • Jirapast Sichaem

摘要

The fruits of Vietnamese Garcinia schomburgkiana were subjected to chemical investigation, leading to the isolation and characterization of a previously unreported benzoylphloroglucinol, 8-benzoyl-2-(4-methylpenten-3-yl)-chromane-5,7-diol (1), along with two known compounds, 8-benzoyl-2-(4-methylpenten-3-yl)-chromane-3,5,7-triol (2) and 5-benzoyl-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene-6,8-diol (3). The structural elucidation was achieved through extensive spectroscopic methods, including NMR and HR-ESI-MS. Compound 1 exhibited good α-glucosidase inhibition with an IC50 value of 30.2 ± 5.3 μM.