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<p>A new biflavonoid derivative, named 4′,5′′-dimethoxy-6,7-(4′′′′,5′′′′-dimethoxy-9′′′′-hydroxymethyl)- phenylpropyl-2′′-(4′′′-hydroxyphenyl)-biflavonoid (<b>1</b>), and seven known biflavonoid derivatives (<b>2–8</b>) were isolated from <i>Citrus medica</i> var. <i>sarcodactylis</i> (Siebold ex Hoola van Nooten) Swingle for the first time. These compounds were elucidated by analyzing their spectral data and comparing them with related references. Among them, compounds <b>1</b> and <b>3</b> exhibited obvious hepatoprotective activities against paracetamol-induced HepG2 cell damage at 10 μM. The results suggested that these compounds could be potential hepatoprotective agents.</p>

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Biflavonoid Derivatives with Hepatoprotective Activities from the Fruits of Citrus medica var. sarcodactylis

  • 期刊论文

  • 发表日期：

    2025年11月19日

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  • Rong-Rui Wei,
  • Wen-Min Liu,
  • Qin-Ge Ma

摘要

A new biflavonoid derivative, named 4′,5′′-dimethoxy-6,7-(4′′′′,5′′′′-dimethoxy-9′′′′-hydroxymethyl)- phenylpropyl-2′′-(4′′′-hydroxyphenyl)-biflavonoid (1), and seven known biflavonoid derivatives (2–8) were isolated from Citrus medica var. sarcodactylis (Siebold ex Hoola van Nooten) Swingle for the first time. These compounds were elucidated by analyzing their spectral data and comparing them with related references. Among them, compounds 1 and 3 exhibited obvious hepatoprotective activities against paracetamol-induced HepG2 cell damage at 10 μM. The results suggested that these compounds could be potential hepatoprotective agents.