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<p>In this study, two new benzochromones (<b>1</b> and <b>2</b>), together with four known ones (<b>3–6</b>), were isolated from <i>Nicotiana tabacum-derived Aspergillus niger</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. All compounds were evaluated for their antibacterial activities against five nitrosobacteria strains (<i>Nitrosomonas communis</i>, <i>Nitrosomonas nitrosa</i>, <i>Nitrosospira multiformis</i>, <i>Nitrobacter winogradskyi</i>, and <i>Nitrospira inopinata</i>). Interestingly, compounds <b>1–6</b> exhibited notable antibacterial activity with bacteriostatic diams in the range of 11.8 ± 1.6 ~ 19.6 ± 2.3 mm against five nitrosobacteria strains, and most of the bacteriostaticic diams were close to that of the positive control. Due to the nitrosobacteria having the ability in tobacco to convert nitrogen components into nitrite, and then convert that into tobacco-specific nitrosamines (TSNAs), the above compounds have the potential to reduce TSNAs in tobacco by inhibiting nitrosobacteria during the fermentation process of tobacco leaves.</p>

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Antibacterial Benzo[g]Chromone from Nicotiana tabacum Derived Endophytic Aspergillus niger

  • 期刊论文

  • 发表日期：

    2025年11月18日

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  • Song-Yi Ji,
  • Hua-Yin Liu,
  • Ling Zhang,
  • Yong Xu,
  • Ying-Liang Zhao,
  • Jin Wang,
  • Jian-Duo Zhang,
  • Qiu-Fen Hu,
  • Jing Li,
  • Rong Zhang

摘要

In this study, two new benzochromones (1 and 2), together with four known ones (3–6), were isolated from Nicotiana tabacum-derived Aspergillus niger. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. All compounds were evaluated for their antibacterial activities against five nitrosobacteria strains (Nitrosomonas communis, Nitrosomonas nitrosa, Nitrosospira multiformis, Nitrobacter winogradskyi, and Nitrospira inopinata). Interestingly, compounds 1–6 exhibited notable antibacterial activity with bacteriostatic diams in the range of 11.8 ± 1.6 ~ 19.6 ± 2.3 mm against five nitrosobacteria strains, and most of the bacteriostaticic diams were close to that of the positive control. Due to the nitrosobacteria having the ability in tobacco to convert nitrogen components into nitrite, and then convert that into tobacco-specific nitrosamines (TSNAs), the above compounds have the potential to reduce TSNAs in tobacco by inhibiting nitrosobacteria during the fermentation process of tobacco leaves.