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<p>In this study, two new pyrroloisoquinolines, cigarpyrro A and B (<b>1</b> and <b>2</b>), together with five known pyrroloisoquinolines (<b>3–7</b>) were isolated from the cigar-tobacco-derived endophytic fungus <i>Aspergillus puniceus</i>. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds <b>1</b> and <b>2</b> were evaluated for their antibacterial activities against five pathogenic strains (<i>Staphylococcus aureus</i> (SEA), <i>Escherichia coli</i> (EPEC), <i>Streptococcus pyogenes</i> (GAS), <i>Bacillus subtilis</i> (QST713), and <i>Proteus</i> spp.). Interestingly, compounds <b>1</b> and <b>2</b> exhibited notable antibacterial activity with a bacteriostatic diameter within the range 15.4 ± 1.8 – 25.2 ± 1.6 mm against the above strains, and most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for compounds <b>1</b> and <b>2</b> used as antiseptic agents were also evaluated, and they have the potential value for use as antiseptic agents for cigarette-tipping paper.</p>

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Antibacterial Pyrroloquinolines from Cigar-Tobacco-Derived Endophytic Fungus Aspergillus puniceus

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Guang-Hui Kong,
  • Hua-Yin Liu,
  • Guang-Hai Zhang,
  • Yu-Long Su,
  • Xue-Ru Song,
  • Wei Li,
  • Wei-Guang Wang,
  • Qiu-Fen Hu,
  • Yu-Ping Wu,
  • Ling-Duo Bu

摘要

In this study, two new pyrroloisoquinolines, cigarpyrro A and B (1 and 2), together with five known pyrroloisoquinolines (3–7) were isolated from the cigar-tobacco-derived endophytic fungus Aspergillus puniceus. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were evaluated for their antibacterial activities against five pathogenic strains (Staphylococcus aureus (SEA), Escherichia coli (EPEC), Streptococcus pyogenes (GAS), Bacillus subtilis (QST713), and Proteus spp.). Interestingly, compounds 1 and 2 exhibited notable antibacterial activity with a bacteriostatic diameter within the range 15.4 ± 1.8 – 25.2 ± 1.6 mm against the above strains, and most of the bacteriostatic diameters are higher than that of the positive control. In addition, the potential values for compounds 1 and 2 used as antiseptic agents were also evaluated, and they have the potential value for use as antiseptic agents for cigarette-tipping paper.