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<p>1,3-Dipolar cycloaddition of benzyl azides to the propargyl ether of the 9-hydroxymethyl derivative of the quinolizidine alkaloid methylcytisine under CuAAC conditions synthesized 9-conjugates of it with 1-benzyl-, 1-(4-methoxybenzyl)-, 1-(2,3-dimethoxybenzyl)-, 1-(3,4-dimethoxybenzyl)-, 1-(2-fluorobenzyl)-, 1-(2-chlorobenzyl)-, 1-(4-bromobenzyl)-, 1-(2,4-dichlorobenzyl)-, and 1-(3-nitrobenzyl)-substituted 1,2,3-triazoles. The structures of the synthesized compounds were confirmed by physicochemical analysis, including elemental analysis and NMR spectroscopy.</p>

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Synthesis of Conjugates of 9-(Hydroxymethyl)Methylcytisine with 1,2,3-Triazoles

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • A. V. Koval’skaya,
  • V. A. Sorokina,
  • A. N. Lobov,
  • I. P. Tsypysheva

摘要

1,3-Dipolar cycloaddition of benzyl azides to the propargyl ether of the 9-hydroxymethyl derivative of the quinolizidine alkaloid methylcytisine under CuAAC conditions synthesized 9-conjugates of it with 1-benzyl-, 1-(4-methoxybenzyl)-, 1-(2,3-dimethoxybenzyl)-, 1-(3,4-dimethoxybenzyl)-, 1-(2-fluorobenzyl)-, 1-(2-chlorobenzyl)-, 1-(4-bromobenzyl)-, 1-(2,4-dichlorobenzyl)-, and 1-(3-nitrobenzyl)-substituted 1,2,3-triazoles. The structures of the synthesized compounds were confirmed by physicochemical analysis, including elemental analysis and NMR spectroscopy.