<p>A previously unreported acyclic monoterpene, zanthungeanumol A (<b>1</b>), and eleven known alkaloids <b>2</b>–<b>12</b> were isolated from the pericarps of <i>Zanthoxylum bungeanum</i>. The activity evaluation showed that compound <b>7</b> exhibited potent antibacterial activities against Staphylococcus aureus, while compound <b>8</b> exhibited significant antimicrobial activity against Escherichia coli 140 with a MIC value of 6.25 μg/mL, and their activities were comparable to the plant-derived antibacterial drug berberine.</p>

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Compounds Isolated from the Pericarp of Zanthoxylum bungeanum and Their Antibacterial Activity

  • Jing-Zhi Zhao,
  • Xiao-Juan Huang,
  • Khalid Hassan Mohamed,
  • Bang-Yin Tan,
  • Wei-Yan Hu,
  • Rong-Ping Zhang,
  • Hao-Fei Yu,
  • Ying Guo,
  • Lan-Chun Zhang

摘要

A previously unreported acyclic monoterpene, zanthungeanumol A (1), and eleven known alkaloids 212 were isolated from the pericarps of Zanthoxylum bungeanum. The activity evaluation showed that compound 7 exhibited potent antibacterial activities against Staphylococcus aureus, while compound 8 exhibited significant antimicrobial activity against Escherichia coli 140 with a MIC value of 6.25 μg/mL, and their activities were comparable to the plant-derived antibacterial drug berberine.